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PhD Scholarship - Cancer Cell Biology

Apply now Job no:504996
Area:Faculty of Medicine
Salary (FTE):APA Scholarship NON-BANDED ($27,082.00 - $27,082.00)
Work type:Full Time - Scholarship
Location: St Lucia

The School of Biomedical Sciences 

The University of Queensland School of Biomedical Sciences is a distinguished centre for teaching and research in the academic disciplines of Anatomy, Developmental Biology, Physiology, Pharmacology and Pathology. The School has more than 40 full-time research and teaching staff and is one of the largest Schools of its type in Australia. It has links to other prestigious research centres on the St Lucia campus including the Queensland Brain Institute (QBI), the Institute of Molecular Bioscience (IMB) and the Australian Institute for Bioengineering and Nanotechnology (AIBN). Our diverse research provides an exciting environment for national and international research fellows and higher degree students. It is concerned with advancing the understanding of how cellular mechanisms contribute to the function of the human body in health and disease.  Details of the research interests of academic staff may be accessed on the school’s web site at https://biomedical-sciences.uq.edu.au/

In addition to its graduate research programs, the School teaches undergraduate students in Science, Medicine, and Health Sciences.

The role

The PhD student will lead an exciting project within the Targeted Protein Degradation Group at the SBMS to study how cell growth and cell cycle proliferation are controlled by ubiquitin-mediated proteolysis.  The group is interested in understanding how ubiquitin ligases (the enzymes that provide the specificity of protein degradation) recognise their target substrates. This is a newly established group at SBMS focusing on understanding how protein degradation controls organelle division, cell cycle progression, centrosome biology, and mitochondrial quality control.

The successful candidate will work in a collaborative, multidisciplinary environment and gain experience performing advanced molecular and cellular biology techniques and advanced cell imaging. The candidate will have the opportunity to be involved in several ongoing research activities in the laboratory, including research publications and presentations.

Please read the following references for background:

Pagan JK, Marzio A, Jones MJ, Saraf A, Jallepalli PV, Florens L, Washburn MP,

Pagano M. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the

PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol.

2015 Jan;17(1):31-43. doi: 10.1038/ncb3076. Epub 2014 Dec 15. PubMed PMID:

25503564; PubMed Central PMCID: PMC4415623.

Skaar JR, Pagan JK, Pagano M. Mechanisms and function of substrate recruitment

by F-box proteins. Nat Rev Mol Cell Biol. 2013 Jun;14(6):369-81. doi:

10.1038/nrm3582. Epub 2013 May 9. Review. PubMed PMID: 23657496; PubMed Central

PMCID: PMC3827686

The person

Expressions of Interest are invited from outstanding and enthusiastic science graduates ideally with a background in cell biology, molecular biology, developmental biology, or other relevant discipline. You should have a strong desire to develop a successful research career, good general research skills, a systematic approach to problem solving, very good writing abilities, and the capacity to work well with others. The successful candidate will be responsible for experimental design, data analyses, and manuscript preparation, and will also be expected to support applications for funding to support their research focus.  Relevant laboratory experience, particularly in sterile tissue culture, Western blotting and microscopy is highly desirable. Demonstrated research capacity (research outputs such as publications or conference presentations) will be highly regarded.

Applicants will have a First Class Honours degree or equivalent must fulfil the PhD admission criteria for the University of Queensland, including meeting English language requirements, and demonstrating excellent capacity and potential for research.

For further information on entry requirements, please visit http://www.uq.edu.au/grad-school/our-research-degrees

The successful applicant is expected to obtain their own tuition fee and living allowance scholarship. For information on scholarships, see https://graduate-school.uq.edu.au/scholarships

Enquiries

To discuss this role and for further information, please contact Dr. Julia Pagan at j.pagan@uq.edu.au

Applications

To submit an application for this role, please complete an online application and provide the following supporting documents:  

  • A cover letter that addresses how you meet the requirements for the PhD program and addressing the desired skills and attributes;
  • A curriculum vitae detailing education, professional experience, research experience, publications, and relevant competencies;
  • Academic transcript for all post-secondary study undertaken, complete or incomplete, including the institution grading scale;
  • Award certificates for all completed post-secondary study
  • The name and contact details of two referees who can best comment on your prior research experience. UQ will contact your referees directly, but you will need to enter their details into the application form.

Advertised:
Applications close: E. Australia Standard Time

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